About FLUENDz

FluEndz - How Influenza Works
& How FluEndz Treats Influenza

The influenza virus invades cells of the respiratory passages.

Its hemagglutinin molecules bind to sialic acid residues on the glycoproteins exposed at the surface of the epithelial cells of the host respiratory system. The virus is engulfed by receptor mediated endocytosis. The drop in pH in the endosome (endocytic vesicle) produces a change in the structure of the viral hemagglutinin enabling it to fuse the viral membrane with the vesicle membrane. This exposes the contents of the virus to the cytosol. The RNA enter the nucleus of the cell where fresh copies are made. These return to the cytosol where some serve as mRNA molecules to be translated into the proteins of fresh virus particles. Fresh virus buds off from the plasma membrane of the cell (aided by the neuraminidase) thus spreading the infection to new cells.

FluEndz works in several different ways by slowing down proteins needed to get viral RNA into the cytosol. At the same time FluEndz attack the neuraminidase and as a result inhibit the release and spread of fresh virions. Spraying FluEndz into the throat within 24 hours of flu like symptoms can shorten the duration of influenza symptoms.

FluEndz shows the ability to inhibit neuraminidase while blocking the hemagglutinin protein, so the latter cannot bind to the sialic acid present on the surface of a healthy cell and thereby gain entry. The compounds were made possible through the use of "click chemistry," which allows scientists to produce large amounts of new compounds quickly. Click chemistry is an approach to synthesizing drug like molecules where a researcher uses a few practical and reliable well-documented reactions to accelerate the drug discovery process.

FluEndz delivery technology is that of Sublingual administrator, which literally means 'under the tongue', from Latin, refers to the pharmacological route of administration by which drugs diffuse into the blood through tissues under the tongue. Many pharmaceuticals are designed for sublingual administration.

When a chemical comes in contact with the mucous membrane beneath the tongue, or buccal mucosa, it diffuses through it. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first pass metabolism" in the liver before entering the general circulation.

Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster, and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein, such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines and the solubility of the GI tract, the oral route is unsuitable for certain substances.

FLUENDz is a flu drug that was developed to provide symptomatic relief of Influenza A, B & C
FLUENDz is a Food and Drug Administration (FDA) registered and regulated over-the-counter drug. In 2009, was given permission by the FDA to manufacture and sell FLUENDz
FLUENDz natural ingredients are approved by the Homeopathic Pharmacopoeia of the United States (HPUS). The HPUS is the official publication for all Homeopathic Drugs in the U.S.
FLUENDz effectively treats up to 12 flu symptoms, including: fever, sore throat, cough, headache, body aches, running nose, chills, congestion, vomiting, nausea, weakness and dizziness
FLUENDz formula is quick and offers fast-acting relief from flu symptoms almost immediately when taken for flu and comman cold symptoms. Due to it's sublingual delivery administration
FLUENDz is safe for all types of people to use, unlike other types of flu medicines.